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Role of Vitamin E as therapeutic agent to cope up with liver functions in chromium treated laboratory chicks

Author: 
Dharmendra Kumar, Vandita Kandpal and Sonu Khanka
Subject Area: 
Life Sciences
Abstract: 

Importance of exogenous application of vitamin E in the acceleration of Cr elemination in the liver function have been discussed in the present investigation. Developing chicks (100±20 gm body weight, 2-3 weeks old) were used as experimental animals. Present investigation revealed that deposition of Cr in all tissues affect the proper function of liver. Liver specific function defence offered by protective influence of vitamin E may be channelized through different mechanism. Vitamin E not only restricted the detoxification but also improved the liver functions. High concentration of Cr was determined in Cr treated chicks. Selective prefrences for chromium was shown by vitamin E for maintaining optimal serum glutamic oxaloacetate transaminase – SGOT (AST), serum glutamic pyruvic transaminase – SGPT (ALT) and alkaline phosphatase (ALP) activity. Vitamin E appreciably improve the detoxication ability of liver. SGOT, SGPT and ALP were significantly increased in chicks treated with chromium compared to normal control group. Chicks treated with vitamin E along with Cr, shows significant decrease in SGOT, SGPT and ALP activity compared to Cr treated chicks where it was high. Hence, elevation in SGOT, SGPT and ALP could be due to biotransformation of heavy metals in liver leading to hepatic injury. This injury may be decreased by the supplimentation of vitamin E in laboratory chicks.

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