In recent years, India has been considered as one of the Earthquake prone countries in the world. Studies are carried out to examine the seismic behaviour of the structure when hit by an Earthquake. Only few of the researchers have researched regarding the effects of vertical irregularities in a Structural Building considering Soil Structure Interaction. In this paper, attempt has been made to study the effects of Vertical Irregularities in a RC Building with and without Soil Structure Interaction. The structure was modelled and Analysed by Response Spectrum Analysis using E-Tabs Software. The structure analysed has been already constructed in Earthquake prone area- Sikkim which falls under seismic zone- IV.