One 7-years-old, three days postpartum, 3rd lactating, approximately 375 kg body weight jersey (Bos Taurus) cow was diagnosed as toxic metritis with mastitis following rectal examination and isolation of Arcanobacter pyogenes, Staphylococcus aureus and E. Coli organisms both in uterine discharge and milk samples besides pyrexia (107⁰C), anorexia, reduced milk yield with hot inflamed udder, copious dark reddish, fetid uterine discharge. On 4th day after treatment cow was confirmed to be suffered from intra-erythrocytic babesiosis and theileriosis based on clinical investigation (pyrexia with pre-scapular, pre-femoral and subcutaneous lymphnodes swelling) and revealing of organisms in blood smear.The cow was treated with Ceftiofur (@2.2mg/kg b.wt. daily for 7 days IM), NS (@20ml/kg b.wt. daily till fever persisted), Megludyne (@2.2mg/kg b.wt. daily for 3 days IV) and Anistamine (@15ml daily for 3 days IM) injection against toxic metritis and mastitis along with intra-uterine and intra-mammary infusions of Lenovo AP (@60ml daily for 3 days) and Cefoperazone sodium (@10ml as single dose) respectively. Diminazine aceteurate (@7mg/ kg b.wt.IM) and Buparvaquone (@2.5mg/ kg b.wt. IM) was given to control the babesiosis and theileriosis. The cow was found recovered normally without recurrence till one month of treatment.