CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Serum levels of se-selectin, TNF-α AND IL-1β IN patients of psoriasis before and after topical therapy in patients of psoriasis

Author: 
Shveta, Kiran Agarwal, Ram Chander and Shilpi Agarwal
Subject Area: 
Health Sciences
Abstract: 

Background: Psoriasis is a T-cell mediated immunological disorder with numerous cytokines and adhesion molecules at play in its pathogenesis. Role of TNF-α, IL-1β and E-selectin has been studied by a few authors. But the studies are very limited in number. We plan to study these markers before and after topical therapy in patients of Psoriasis. Aims and Objectives: To study the serum levels of sE-selectin, TNF-α and IL-1β in patients of psoriasis and compare them with controls, Psoriasis Severity index and with each other. Material and Method: A prospective study of patients presenting with newly diagnosed Psoriasis at Dermatology OPD of Smt. Sucheta Kriplani Hospital, New Delhi. Follow-up was done after topical therapy with Coal tar, Salicylic acid and Dithranol. A total of 6 patients could be followed up. Serum samples were taken for ELISA determinations of TNF-α, IL-1β and sE-selectin at diagnosis and at 6 months follow-up visit. Results: In the present study the cases ranged from 8 to 50 years. Four patients had psoriasis vulgaris, 1 had Palmoplantar psoriasis and one had Pustular psoriasis. PASI Score ranged from 1.6 to 8.8. sE-selectin level in cases was 177.4±81.21ng/ml and reduced after therapy to 101.17±34.64ng/ml (p=.092). TNF-α level in cases was 32.05±42.27 pg/ml and reduced after therapy to 14.31±15.25pg/ml (p=.201). IL-1β levels in cases was 20.78 ±18.80 pg/ml and after therapy the levels reduced to 9.13±5.74 (p=.210). Conclusion: sE-selectin, TNF-α and IL-1β levels are increased in patients with psoriasis vulgaris as compared to controls. After therapy the levels reduce from the initial value but not enough to reach a statistical significance and remain higher than controls. This shows that these markers play an integral role in the pathogenesis and can be essential targets in formulation of newer therapies. Further studies as required to advance our knowledge in possible newer treatments for Psoriasis.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran