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Sesamol exerts antihypertensive and renoprotective effects in a rat model of doca-salt-induced hypertension

Author: 
Govindasamy Hemalatha, Kodukkur Viswanathan Pugalendi, and Ramalingam Saravanan
Subject Area: 
Life Sciences
Abstract: 

This study aims to evaluate the effect of sesamol on blood pressure, and renal function markers on uninephrectomized deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Hypertension was induced in surgically single-kidney-removed (left), adult male albino Wistar rats, weighing 180-200 g, by injecting DOCA (25 mg/kg BW) subcutaneously, twice a week for six weeks, with saline instead of tap water for drinking. Every week, the blood pressure was measured and documented up to six weeks for all the animals. DOCA-salt hypertensive rats showed considerably increased blood pressure, heart rate, proteinuria, renal function markers (urea, uric acid and creatinine) in plasma and sodium levels in urine. In addition, hypertensive rats showed a decreased body weight and potassium excretion. Oral administration of sesamol (50, 100 and 200 mg/kg BW) brought back all the above parameters to near normal level. The effect at a dose of 50 mg/kg BW of sesamol was more pronounced than that of the other two doses. These findings indicate that sesamol exhibits strong antihypertensive and renoprotective effects in DOCA-salt hypertensive rats.

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