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In-silico identification of putative drug targets of chlamydia psittaci 6bc by subtractive genome approach

Author: 
Khalida Naveed, Ahsan Jabbar and Syeda Tatheer Fatima
Subject Area: 
Life Sciences
Abstract: 

Chlamydia psittaci is a pathogenic and bio-warfare agent that causes infections in multiple hosts including birds and mammals. In human, it mostly causes severe lung diseases that are associated with high motility rate. This pathogen also causes a major setback to the world economy. Therefore, there is an urgent need to develop antimicrobial agent that can cure infections caused by these agents. In the present study, we have predicted number the possible putative drug targets against it with the aid of subtractive genome approach along with their subcellular localization, drugable potential and involvement in essential metabolic pathway. Furthermore, we have also predicted the 3D molecular structure using structural homology methodology with of one of the identified drug target that affect the isoprenoid biosynthesis in C. psittaci (a crucial pathway needed by the pathogen to survive). After molecular modeling, we also performed molecular docking to predict the possible binding mechanism of the selected protein with its ligand. This study can be utilized to identify potent inhibitor of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase protein by virtual screening of number of chemical entities against the modeled protein.

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