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Stability indicating validated dissolution method for determination of propranalol and hydralazine by multicomponentmode method and second order derivative method

Author:

Hajera Khan, DhotreLaxmi, A. G Mangulkar., MD Zameeruddin

Subject Area:

Physical Sciences and Engineering

Abstract:

The aim of this work was development and validation of a dissolutionmethod for Propranolol and Hydralazine (Carbetazine Tablets). The dissolution established conditions were 900 mL of 0.1M HCl (pH 1.0) as dissolution medium, using a paddle apparatus at a stirring rate of 50 rpm. The drug release was evaluated by UV spectrophotometric method the absorbance of solution were recorded at288.20nm and 259.20nm for Propranolol and Hydralazinemixture for Multicomponent Mode methodand at 221.8nmand 243.36nm for Propranolol and Hydralazine respectively for Second order derivative method .Ahead of the results it can be concluded that the method developed consists in an efficient alternative for assays of dissolution for tablets.

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