
Introduction: Thermoregulation is the ability of neonates to balance heat production and heat loss in order to stabilize internal body temperature. The neonates have special requirement for temperature maintenance due to large surface area in relation to body weight, less adipose tissue and subcutaneous fat and underdeveloped sweating and shivering mechanism. All neonates including term, preterm and SGA are at risk of heat loss especially during first 12 hours of life. Aim: To assess the effectiveness of structured teaching programme on knowledge of mothers regarding thermoregulation in neonates in selected hospital of Ludhiana, Punjab. Material and Method: A quasi-experimental approach with two groups pre-test and post test research design and purposive sampling was used. A self structured questionnaire was used which had two parts demographic data and questionnaire to assess the knowledge of mothers. Structured teaching was conducted on the experimental group. Analysis of data was done using descriptive and inferential statistics. Results: The data was analysed by using descriptive and inferential statistics. The pre-test knowledge score was almost same i.e average knowledge in both the groups. In control group maximum mothers obtained average knowledge score whereas in experimental group majority of mothers obtained good post-test knowledge score. The difference between pre test and post test knowledge score of control group was statistically non- significant at p< 0.05 level but in experimental group it was statistically highly significant at p< 0.001 level. Conclusion: The study concluded that structured teachings programme was significantly effective in raising the knowledge of mothers regarding thermoregulation in neonates.