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Study of carotid intima media thickness and apache ii(acute physiological and chronic health evaluation) and short term mortality in acute ischemic stroke

Author: 
Siddiqui, M. S., Pankaj Verma, Jalees Fatima and Priya Singh
Subject Area: 
Health Sciences
Abstract: 

Objectives: The present study was carried out with an aim to detect correlation of CIMT, APACHE II and short-term mortality in patients with acute ischemic stroke. Methods: After ethical considerations, this prospective observational study was conducted on 50 patients of acute is chenic stroke. The diagnosis of ischemic stroke was based on the clinical profile and confirmed by CT / MRI as defined by ASA/AHA. Results: Among the 50 patients studied age of patients with acute ischemic stroke ranged from 45-78 years with a mean age of 61.18±7.59 years. Majority of patients were in 51-70 years of age (n=43; 86%).On day 1 of admission APACHE-II scores ranged from 11 to 33 with a mean value of 19.80±6.17.Day 3 APACHE score range expanded with minimum and maximum values being 8 and 34 respectively. Day 3 mean APCHE II scores were 19.50±6.80.On day 7, the range of APACHE II scores was 8 to 38 with a mean value of 22.54±9.71.Average CIMT value ranged from 0.055cm to 0.11cm with a mean value of 0.075±0.013. After one month, a total of 11 (22%) patients showed improvement, 13 (26%) showed survival without change in status. A total of 14 (28%) were lost to follow up and a total of 12 (24%) expired. Cause of mortality was ascertained as aspiration/pneumonia in majority (n=5; 41.67%), 2 (16.67%) expired owing to sepsis, 2 (16.67%) due to sepsis/AKI, 1 (8.33%) patient each died due to reinfarct/sepsis, atrial fibrillation/reinfarct and inability to feed respectively. Conclusion: Carotid intima media thickness in acute ischemic stroke patients did not provide any useful information with respect to outcome (short term mortality). There was some association of constituents of APACHE-II scores and short term mortality.

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