To study the efficacy of dexmedetomidine for attenuation of hemodynamic responses in patients undergoing laparoscopic surgeries

Background: Hemodynamic stability during peri-operative period is of vital importance. The anaesthesiologist’s conventional approach to provide anaesthesia for laparoscopic procedures has been the emphasis on maintaining hemodynamic stability by avoiding hypertension, hypotension and tachycardia. Objectives: To study • Hemodynamic responses associated with Intubation and Pneumoperitoneum. • Associated adverse effects like Bradycardia and hypotension. Methods: Prospective double blinded randomized clinical study was conducted in the department of Anaesthesia. Ethical Committee permission- Taken Informed written consent- Taken Total of 90 patients scheduled for Laparoscopic surgeries were allotted into two groups. Group D (Dexmedetomidine): IV Dexmedetomidine loading dose 1mcg/kg and maintenance dose of IV Dexmedetomidine infusion at 0.4mcg/kg/min. Group S (Normal saline): IV Normal saline 0.9% (1ml) loading dose and maintenance IV infusion at 1ml/min. Statistical Tests used were Chi square test, unpaired t test and Mann-Whitney test. Inclusion criteria • Age 18-60 years of age. • ASA grade I and II. Exclusion criteria • Patients with heart blocks • Morbid obese. Results: Conclusion: Perioperative IV Dexmedetomidine was found to be effective in providing Hemodynamic stability during laparoscopic surgeries without any significant adverse effects.