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A study on evaluation of phospholipase A2 gene polymorphism and the expression in terms of phospholipase A2 enzyme in preeclampsia

Author: 
Nagarjuna Sivaraj, Dayanand, C. D. and Sheela, S. R.
Subject Area: 
Life Sciences
Abstract: 

Aim: Our purpose was to know phospholipase A2 activity and its gene PLA2G4α polymorphism was an inflammatory marker in preeclampsia compared with normotensive pregnancies. Efforts were made to determine the association of PLA2 and its gene. Study Design: Longitudinal observational study Methods: 4ml of blood was obtained from preeclampsia (n=51) and normotensive pregnants (n=51). They were maternal age, gestational age, parity matched. Phospholipase A2 activity was determined by colorimetric method and PLA2G4α polymorphism was evaluated by PCR-RFLP techniques. Results: When HW equation is applied to this observation of controls population (p=0.66) and in preeclampsia cases (p=0.76) it states that allele and genotype frequencies of PLA2G4α gene in a population will remain constant. Phospholipase A2 enzyme activity in control population was 1.80units/mg with SD ±0.225, in preeclampsia was 2.47 unit/mg with SD ±0.0112 with significance of P<0.001. Conclusion: Results indicated that there was no polymorphism in the PLA2G4α gene structure, but the difference in gene expression in comparison of two groups was marked in terms of measuring the enzyme activity with p value (p<0.001). PLA¬2 can be used to understand the intensity of inflammation in preeclampsia. However, further studies are necessary to evaluate PLA¬2 activity in each trimester of preeclampsia, eclampsia and placental contribution to any PLA activity.

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