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A study of lipid profile and its correlation with clinical outcome and in-hospital mortality in patients with intra cranial Haemorrhage

Author: 
Dr. Mahesh Dave, Dr. Aniruddha Burli and Dr. Mukesh Jiterwal
Subject Area: 
Health Sciences
Abstract: 

Introduction: Stroke is an emergency requiring urgent investigation and treatment. It remains a major cause of mortality and disability worldwide. The association between lipid profile and stroke remains uncertain. This study therefore investigated whether changes in lipid profile might contribute to the risk of ICH. Materials and Methods: This is a case control which included 50 patients of ICH as cases and 50 persons of same age and sex as controls. Serum lipid profile was done which consisted of Total Cholesterol, High density lipoprotein cholesterol, Low density lipoprotein cholesterol and Triglycerides. The diagnosis was ascertained based on Non-Contrast Computed Tomography of Head, done at the time of admission. The correlation of lipid profile and clinical outcome was studied. Result: In our study, 68% were males and 32% were females in case and in control group 58% were males and 42% females. All the levels of different lipid components were significantly different except HDL. The mean LDL for death patients was 109.62±38.17 and for discharged patients was 89.23±28.01. The mean level of triglycerides for discharged group was 110±45.76 and for death group was 85.14±37.20. Conclusion: Our study concluded that there is significant correlation between lipid profile, specifically LDL-C and Triglycerides and clinical outcome of ICH patients in terms of death or discharge. Low levels of LDL-C and Triglycerides are associated with poor outcome in patients with ICH.

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