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A study of oxidative stress and antioxidant enzymes in obesity

Author: 
Ramesh Pradhan, Vijay Pandhare, Jayshree Tolani and Rosy Lekharu
Subject Area: 
Life Sciences
Abstract: 

Obesity is a growing social problem. Obesity can restrict the quality of life and make the person susceptible to a plethora of chronic systemic diseases like Coronary artery disease, Hypertension, Diabetes mellitus, metabolic syndrome and even cancers. Obesity leads to a low grade inflammatory state which creates an oxidative stress in the body. The oxidative stress measured in obese individuals versus normal controls show an increased oxidative stress in the former putting them at increased risk of complications. We found that with increasing Body mass index the oxidative stress increased as seen in the rise of Malondialdehyde (158%) and fall of Glutathione peroxidase (20.76%), Glutahione reductase (29.45%) and Vitamin C (21.7%) which when compared between the two groups is statistically very significant (p<0.0001).

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