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Study of oxidative stress and serum Paraoxonase 1(PON 1) in essential hypertension

Author: 
Dr. Diptimayee Jena, Dr. Nirupama Devi, Dr. Itishri Jena, Dr. Rashmita Kumari Padhy, Dr. Pramila Kumari Mishra
Subject Area: 
Health Sciences
Abstract: 

Aim and Objectives: Essential hypertension accounts for more than 90% of cases of hypertension. It is one of the most important risk factors for cardiovascular diseases and other clinical outcomes. Even though lot of research has been done for the treatment and prevention of hypertension. The present study was carried out with the objective to find out correlation between oxidative stress and paraoxonase 1 in hypertension (HTN). Methods: The study was carried out on 90 hypertensive patients and 90 normotensive controls. Cases with diabetes mellitus, thyroid disease, chronic kidney disease, smoking, autoimmune diseases and any other chronic diseases are excluded. The study was approved by Institutional ethical committee. Informed consent was obtained from all cases. Serum PON 1 was estimated by ELISA method using commercial kit procured from Aviscera Bioscience, total oxidant load by FOX 2 assay and total antioxidant capacity by FRAP assay. Statistical analysis was done by SPSS version 20 software. Results: serum total oxidant load (FOX 2) was increased and serum total antioxidant capacity (FRAP) and antioxidant enzyme (PON 1) was decreased in hypertension. There was a negative correlation between serum FOX2 with serum FRAP and PON1 level Conclusion: Oxidative stress which is responsible for pathophysiology of hypertension, causes decrease in total antioxidant capacity. PON 1 is an antioxidant enzyme present on the surface of HDL also significantly decreased which is responsible for prevention of HTN and it’s complications.

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