Background: Acute poisoning is a commonly encountered medical emergency and is a leading cause of morbidity and mortality. Poisoning was a common mode of suicide and is an important part of medicolegal cases. Materials and Method: Prospective study of 100 admitted cases of poisoning from 2015-2018, Admitted at emergency department. The cases were studied regarding epidemiological profile, distribution of poisons, Nature of poison. Results: Out of 100 prospective cases, 68 were males and 32 were females, Male female ratio is 2.12:1. Maximum number of cases were observed between 21-30 years (52%) followed by 11-20 years (22%). 72% cases were married and 28% were unmarried. Urban area Reported higher incidence as compared to the Rural area. Suicidal poisoning was reported to be the highest (70%) followed by accidental (28%) and homicidal (2%). In these cases, most of them were agriculturists (32%), followed by students (29%), housewives (22%). Among the expired 7 cases none of them arrived at hospital in or before 3 hours, more than half of the victims arrived at the hospital after 3 hours. Commonest agent involved is organophosphate (48%), followed by organochloride (22%), sedatives (10%). Conclusion: Organochemicals were the commonest agents used in poisoning.