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A study of serum glucose in relation to serum uric acid in Prediabetes, Type 2 Diabetes Mellitus patients and Normoglycaemics

Author: 
Dr. Nimmy Maria James, Dr. Vibha. C and Dr. H. L. Vishwanath
Subject Area: 
Life Sciences
Abstract: 

Background: Several epidemiologic studies have reported that high serum uric acid levels are strongly associated with prevalent health conditions such as obesity, insulin resistance, metabolic syndrome, essential hypertension and renal disease. There has been a growing interest in the association of hyperuricemia with hyperglycaemia. Thus, the study is conducted to investigate the association of serum uric acid with deterioration in glucose metabolism. Objectives: 1) To measure Serum fasting blood glucose (FBG) and Serum Uric Acid in prediabetics, Type 2 Diabetes Mellitus patients and normoglycaemics. 2) To assess the correlation between Serum FBG and Serum Uric acid in the above patients. Material and Methods: Case Control study of 30 prediabetics, 30 Type 2 DM patients of age group 20-85 years in Victoria Hospital, attached to Bangalore Medical College and Research Institute, Bangalore and 30 healthy individuals of same age group with no family history of Type 2 DM from general population. Data analysis was done by Pearson’s Correlation analysis, Chi square test and Student’s t test. Results: Mean serum uric acid levels in prediabetics is 6.903±0.42mg/dl, Type II Diabetes Mellitus is 2.97±1.01mg/dl and in normoglycaemics is 3.5±0.54mg/dl respectively. There is a positive correlation of FBG and Uric acid in prediabetes and a negative correlation in type II DM and both are statistically significant (p<0.00001). In normoglycaemics, uric acid shows a positive correlation but statistically insignificant (p=0.424) Conclusion: Fasting serum uric acid levels were higher in prediabetic population but lower in people with diabetes than in normoglycaemic people. Therefore uric acid may serve as the potential biomarker of deterioration in glucose metabolism.

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