Study of serum leptin levels with histological grading and receptor status in breast cancer patients with metabolic syndrome

Objectives 1)To measure serum leptin level in patients with carcinoma breast 2)To study the correlation between metabolic syndrome as well as its individual parameters and grading and receptors in patients of carcinoma breast 3)To evaluate rise of serum leptin levels in patients with carcinoma breast with metabolic syndrome(MS) in comparison to values in patients with breast cancer without MS. Method: A cross sectional study was carried out with 66 patients of proven carcinoma breast. Serum leptin of all the patients were analysed using ELISA. All the parameters of MS were recorded individually as defined according to NCEP-ATP3(National Cholesterol Education Program and Adult Treatment Panel). Histopathological grading was done by using SEER and modified bloom Richardson grading. The data was carefully tabulated in a proforma and statistically analysed by statistician using SPSS. Results: In our study out of 66 ,38 (57.57%) patients were in TNBC group and 28 (42,42%)in receptor positive group.The mean age in receptor positive group was 49.32= 14.56 and in TNBC 51.16=10.47.in receptor positive group 85.7% had waist circumference >80cm and in TNBC group 73.7% had WC >80 cm . Total 32 (48.48%) patients had MS, in receptorpositive group 13/28(46.43% had MSand 15/28(53.57% did not fall in MS category, however in TNBC 19/38(50%) had MS and equal no 19/38(50%)did not have MS and the P value obtained was 0.716 which was statistically non significant. Inreceptor positive group 28.57% had grade 3 histological grading and in receptor negative group 52.63% patients had grade 3 histology.In receptor positive group 6/28 (21.4% )had serum leptin levels were <11.1 pg/dl and 22/28 (78.6%) had serum leptin level >11.1%.In TNBC group 4/38 (10.5%) patients had serum leptin level <11.1pg/dl and 34/38(89.5%) patients had serum leptin level >11.1 pg/dl and the P value obtained was 0.03 which was statistically significant. Conclusion: Thus the increased serum leptin levels have strong correlation with TNBC and high grade breast cancers and correlation with MS was equivocal .The correlation with Ki 67 was also statistically significant while comparing both groups.