To study various inflammatory markers in type 2 diabetes mellitus

Introduction: Diabetes Mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. Impaired glucose tolerance and hyperglycemia are the main clinical and diagnostic features and the result of an absolute or relative insulin deficiency or resistance to its action. Aims and Objectives: To study various inflammatory markers such as ESR, CRP, Serum albumin and Ferritin and their correlation in type 2 Diabetes Mellitus patients. Material and Methods: The present study was carried out in 50 Diabetes Mellitus type 2 patients (cases) and 50 age and gender matched individuals (control) in MBGH hospital and RNT Medical College, Udaipur over the period of 12 months. Results: Mean age of patients was 59.50 ± 11.06 years. Females out numbered males 1.5:1. Patients of case group had dyslipidemia, total cholesterol (257.70 ± 49.49), triglycerides (203.52 ± 83.62), LDL was 124.30 ± 29.99 and HDL was 35.67 ± 7.62. Serum ferritin was found to be very high (511.09 ±390.37) in patients with diabetes mellitus as compared to control group (106.60 ± 30.19), the difference was statistically highly significant. Same was the case with ESR and CRP levels. This showed strong association of increased inflammatory markers with diabetes mellitus. Also, serum albumin was decreased in cases as compared to controls; which was statistically significant. There was a positive correlation between duration of Diabetes Mellitus type 2 with inflammatory markers (Ferritin, albumin). Also, inflammatory markers like ESR, CRP and albumin had coorelation with HbA1c values. Conclusion: Diabetes Mellitus type 2 has a close association with inflammatory markers and dyslipidemia such as raised ESR, CRP, Ferritin and decreased albumin. These markers are associated with uncontrolled hyperglycemia and increased risk of various complications ; thus , they can serve as a prognostic marker