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Superiority of antigen detection over antibody detection in the diagnosis of visceral leishmaniasis

Author: 
Kumar Rajesh and Kumar Sanjay
Subject Area: 
Life Sciences
Abstract: 

Visceral Leishmaniasis (VL) also known as Kala-azar (Hindi: kala means black, azar means sickness, also known as Assam fever, Dumdum fever, Sikari disease, Burdwan fever, Shahib's disease and tropical splenomegaly). This disease is endemic and widely spread in 88 countries, including India. Because of its importance, was selected by WHO out of six most precarious diseases. Due to diversity of epidemiological situations, no single diagnosis treatment, or control will be suitable for all. Serological tests which have been used and evaluated are aldehyde test, Napier Test, Complement Fixation Test Direct agglutination test, Immuno-fluorescent test, Enzyme linked immunosorbent assay Immuno-chromatographic dipstick test for VL diagnosis. They all are based on detection of antibody titre in patients serum, but antigen detection is most superior diagnostic test over antibody, as in this case HIV-Co infected can be easily detected because there antibody titre is very low and can’t be detected upto a certain limit.

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