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Synthesis and bioactivity of 3-(1-alkyl-4-aryl-6-thioxo-1, 6-dihydro-1, 3, 5- triazin- 2- yl)-amino-2-aryl-3, 4-dihydro-4-oxo-2 h- 1, 3-benzothiazines

Author:

Meena K Yadav, Bal Krishna Singh and Laxmi Tripathi

Subject Area:

Health Sciences

Abstract:

A series of novel 1,3,5-triazinyl benzothiazine derivatives have been prepared by condensation of N-[1-alkyl]4-aryl-6-thioxo-1,6-dihydro-1,3,5-triazin-2-yl]-N’-arylidenhydrazine with 2-mercaptobenzoic acid. The structure of the new compounds has been established by elemental, spectral and m.p. studies. All the compounds have been subjected to antibacterial and antifungal screening. In the series, compounds with chloro- inhibit the growth of S. aureus at MIC of 1.22 μg/mL whereas in the antifungal testing compounds 6d, 6i, and 6l are more potent than standard drug and zone of inhibition was more against A. fumigatus.

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