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Synthesis, characterization and biological studies of 9-aryl substituted acridinedione derivatives by hantzsh condensation

Author: 
Nalini, V. and Girija, R.
Subject Area: 
Physical Sciences and Engineering
Abstract: 

Nearly twenty four acridinedione derivatives are prepared by thermal method using P2O5 / ethanol catalyst. The same compounds are prepared by solvent free green approach involves the exposure of neat reactants to microwave irradiation of three component reaction of dimedone, aromatic aldehydes and amines in a stoichiometric ratio 2:1:1 for few minutes afforded the formation of stable acridinedione derivatives in an excellent yield (80-95%). The structure of all the products has been characterized by IR, 1H, 13C NMR and mass spectral studies. The percentage of yield and purity is compared and found to be excellent in greener method and this method is found to be environmental friendly.

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