Synthesis of nanoparticulate system for controlled release of drugs, with thermal, structural, morphological and magnetic properties

Iron oxide magnetic nanoparticles (IONPs) have been used in biomedical applications as carriers for drug delivery, magnetic resonance imaging, magnetic hyperthermia and thermoablation, bioseparation and biosensor applications. The aim of this study was to synthesize magnetite nanoparticles coated with silica and functionalized with Octadecyl Trimethoxy silane for future aggregation of anti-tumor, anti-inflammatory and other drugs in the intention of guided administration by external magnetic systems such as: nuclear magnetic resonance, electromagnets and Neodymium magnets. Magnetic IONPs were synthesized by oxidation method adapted from literature, coated with silica, functionalized with Octadecyl Trimethoxy silane and saturated with Doxorubicin solution for future biomedical applications. The coated and functionalized magnetic IONPs were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG), particle size and morphology by scanning electron microscopy (SEM) and magnetic properties analysis (ZFC curves). The analyses revealed that the functionalization of the coating and the incorporation of antitumor did not interfere with the magnetic properties of magnetite. The nanoparticles obtained are within the expected parameters for application as a guided drug delivery system.