Background: To increase The reaction of Ethyl 5-(morpholinomethyl) furan-2-carboxylate with 4-amino salicylic acid afford a of 2-Hydroxy-4-(5-(morpholinomethyl)) furan-2-carboxamido)benzoic acid (MPFSA).. The transition metal complexes of Cu2+,Co2+ ,Ni2+, Mn2+ and Zn2+ of MPFSA have been prepared. The objective of the research work is synthesis, characterization and chelating properties of furan ring containing organic ligands to monitor its antimicrobial activity. MPFSA and all the metal complexes were characterized by elemental analyses, spectral studies, magnetic moment determination, molar conductivity measurement. The free ligand and it’s complexes have been tested for their antibacterial activities against two types of human pathogenic bacteria the first group is gram positive while the second group is gram negative (by using agar well diffusion method). Finally, it was found that compounds show different activity of inhibition on growth of the bacteria. The conclusion is Ni(II) Cu(II) ,Co(II) and Mn(II) complexes possess octahedral geometry around the central metal ion.
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