Tinospora cordifolia (Willd) Miers. is commonly called as ‘Guduchi’, ‘Amrita’ in Ayurveda. It is a well known medicinal plant for its massive application in the treatment of various diseases, motioned in the ancient and traditional Ayurveda literature. It is a glabrous, perennial, deciduous, climbing shrub of weak and fleshy stem spread across the Tropical India and Andaman. Many potential therapeutic properties have already been reported by various modern scientific researches. But lots of ancient clinical applications of this medicinal herb need to promote for widespread utilization globally. Hence present review aimed to analyze the extensive therapeutic application of this plant mentioned in different classical texts of Ayurveda. Review suggests for additional bunch of scientific studies on wide-ranging pharmacological properties of the plant, available in ancient classical literature of medicine.