The purpose of the study was to determine the effectiveness of public policies against trafficking in persons in the Madre de Dios district. The current of thought that guided the research was the paradigm is interpretive, with a qualitative approach and design of evaluative cases; Information gathering was done through interviews with social actors that are related to the problem, documentary review and participant observation. From the evidence found, it is determined that public policies and management by national, regional and district government bodies to eradicate trafficking in persons in the form of sexual exploitation have not been efficient in the period 2011 - 2016. The factors that affect policy compliance were determined to be: geographical, political, socioeconomic, communication and human.