CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2018

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

Tumor suppressor in oral carcinogenesis

Author: 
Prajakta R. Zade, Alka H. Hande, Minal S. Chaudhari, Madhuri N. Gawande, Amol R. Gadbail, Swati K. Patil, Dipak D. Ghatage and Satyajit A. Tekade
Subject Area: 
Health Sciences
Abstract: 

Introduction: The biology and regulation of p73, a p53 homologue is complex, since the gene incorporates both tumor-suppressive and protooncogenic functions. However, the p73 gene is rarely mutated in tumors. A better understanding of p73 pathway is mandatory for the improvement of oral cancer diagnosis and treatment. Aim: The aim of the present study was to evaluate p73 expression in oral potentially malignant disorders compared to oral squamous cell carcinoma. Methods & Materials: p73 expression was assessed in 30 oral squamous cell carcinoma, 30 oral potentially malignant disorders & 10 normal oral mucosa. The immunohistochemistry was carried out by using rabbit anti-human antibody against p73. Results: The Kruskal-Wallis test showed significant increase in p73 expression from normal oral mucosa to potentially malignant disorders to oral squamous cell carcinoma (p=0.00). Using Mann-Whitney test, the p73 expression was significantly higher in severe dysplasias than moderate and mild dysplasias (p=0.00). Similarly, the p73 expression was significantly higher in poorly differentiated squamous cell carcinomas than moderately and well differentiated squamous cell carcinomas (p=0.00). However, p73 expression was statistically insignificant (p=0.853) between severe dysplasia and well differentiated squamous cell carcinomas. Conclusion: The results suggest that p73 acts as a tumor suppressor gene in oral carcinogenesis. From this evidence, it is likely that p73 protein isoforms are instrumental for the maintenance of head & neck squamous epithelial stem cells and progenitors. Conversely, loss of p73 expression is associated with keratinocyte differentiation. Therefore, it is proposed that p73 probably plays a role in the maintenance of stem and progenitor cells, leading to the control of early epithelial differentiation stages.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR
Rosane Cavalcante Fragoso, Brasil
ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran