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Ultrasound elastography evaluation of breast masses with fnac and/or histopathological correlation

Author: 
Dr. Ashwini Bakde and Dr. Prajwalit Gaur
Subject Area: 
Health Sciences
Abstract: 

Background & Objectives: Ultrasound elastography is a non-invasive method for determining tissue mechanical properties. The aims of were to study: 1. The sensitivity and specificity of ultrasound elastography in the detection and characterization of various breast masses. 2. The role of ultrasound elastography in differentiating benign and malignant breast masses with FNAC and /or histopathology correlation. 3. Determine an optimal cut-off value for the traced area ratio by receiver operating characteristic (ROC) analysis for differential diagnosis in future applications. Methods: It is a Hospital based prospective study carried on Philips iU22 ultrasound machine with high frequency probe, colour Doppler, and sono-elastography for 2.0 years on 116 cases. Patients presenting with small palpable breast lesions and those incidentally detected lesions on mammography were included in the study. Patients not willing for Ultrasonography & FNAC or Histopathology were excluded from the study. Results: Among the benign nodules the common lesions were fibroadenoma 22 (19%) cases. Among the malignant lesions, the most common lesion was ductal carcinoma (invasive) 34 (29.3%). The mean elasticity score for benign lesions was 1.90 and 4.21 for malignant lesions. A sensitivity of 83.9% and a specificity of 91.7% was obtained for elasticity score with a cut-off point of 3. A sensitivity of 91.1% and a specificity of 88.3% was obtained for strain ratio with a cutoff point of 2.94. Interpretation & Conclusions: The present study shows elasticity score (qualitative) and strain ratio (quantitative) methods in ultrasound elastography are good for the diagnosis of benign and malignant breast lesions with high sensitivity as well as high accuracy rate.

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