This article reviews the pulpotomy medicaments which were studied in the dental literature and discusses their advantages and disadvantages. Many of the newly suggested medicaments have shown promising results in vitro and in vivo in the short run; however, the evidence is still insufficient to identify one superior pulpotomy medicament. There is clearly a need for long-term studies with the highest level of evidence (randomised controlled trials) to identify the best medicament for pulpotomy of primary teeth .It is important to identify a novel, effective and preferably natural pulpotomy medicament to increase the therapeutic arsenal and successfully perform pulpotomy procedures.
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