Many natural products including medicinal plants have been contributed in the development of drugs or antimicrobials thus spices retaining medicinal particularly antimicrobial potentials have also played a great role in this field. Carum carvi (black cumin), Elettaria cardamomum (green cardamom), and Cinnamomum zelanium (Cinnamon) has shown their beneficial effects against some of the clinical isolates including Staphylococcus aureus, Enterococcus sp., Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, Acenatobacter sp., Proteus sp., and Escherichia coli that are becoming extremely disappointed problems in present days and have failed to respond the previously active drugs. So it is important to explore various natural products to find new of this type as preventive measures. In this regard spices can be correctly said to natural antimicrobials.