Significance of serum concentration of hemerine in the assessment of coronary disease in diabetes

Background:Coronary artery disease is a major vascular complication of type 2 diabetes mellitus with a high mortality rate. Serum hemerin levels are involved in glucose and lipid metabolism and are associated with multiple cardiovascular risk factors. The aim of this study is to investigate the association and significance of serum chemerin concentration with the presence of coronary artery disease in patients with type 2 diabetes mellitus. Methods: The study is retrospective-prospective, clinical, comparative, descriptive. The sample of the study was patients from the internal ward of Travnik hospital (86 subjects), who had coronary angiography. One group was made up of type 2 diabetes mellitus (37 subjects) and the other group was non-diabetic subjects (49 subjects). All subjects were analyzed for serum chemerin concentration and coronarography performed. Results of the study: In the cohort of diabetic subjects, 57.4% had coronary disease and in the control cohort, 42.6%. The serum concentration of chemerin is significantly higher in the cohort of subjects with diabetes and coronary disease compared to the cohort of non-diabetic subjects. The serum concentration of chemerin does not depend on the severity of the coronary disease, although it does depend on its presence. Logistic regression analysis showed that serum chemerin concentration was an independent determinant of the presence of coronary artery disease in subjects with diabetes (OR = 1.037; 95% CI = 1,000 to 1,076; p≤0.05). In addition, linear regression analysis showed that the serum concentration of chemerin had a positive statistically significant association of different strengths, with the following relevant relevant parameters analyzed: waist circumference, HbA1C, cholesterol, triglycerides, BMI, and cardiovascular risk level, until statistically significant coronary disease severity was established. significant connectivity. Conclusion: Elevated serum chemerin levels may be considered an independent predictive marker of the presence of coronary artery disease in patients with diabetes.