Exploring the corelation between asymmetry rate of the cerebral peduncle and the recovery of poststroke aphasia

Objective: To explore the corelation between asymmetry rate of the cerebral peduncle (ARCP) and the recovery of poststroke aphasia (PSA). Methods: Thirty-three recurrent stroke participants with PSA completed the retrospective study. They were divided into two groups according to the sides of recurrent stroke, ipsilateral group (dominant side) and contra lateral group. The aphasia quotient (AQ) of post-first time stroke (AQpostFS), pre-recurrent stroke (AQpreRS), and post-recurrent stroke (AQpostRS) were collected, which were based on the Chinese version western aphasia battery. The ARCP was calculated based on the latest magnetic resonance imaging (MRI). Changing of AQ (∆AQ, ∆AQ1= AQpreRS-AQpostFS; ∆AQ2= AQpreRS-AQpostRS), and the correlation between ∆AQ and ARCP of the two groups were analyzed. Results: The AQpostRS of the contralateral group is significantly lower than that of the ipsilateral group (32.42 [18.73] vs. 44.97 [11.65], p=0.029).∆AQ2 in CG was higher than that in IG (38.54 [17.89] vs. 27.03 [10.76], p=0.034).∆AQ1 (r = 0.792, p<0.0001) and ∆AQ2 (r = 0.940, p<0.0001) showed a significant correlation with ARCP. Subjects with an ARCP of more than 1.5 presented a higher ∆AQ2 than patients with ARCP less than 1.5 In CG (56.77 [2.98] vs. 25.77 [11.11], p<0.0001), a contrary consequence was observed in IG (19.08 [11.44] vs. 30.64 [8.68], p=0.042). Conclusion: Patients with higher ARCP showed a worse prognosis of PSA followed recurrent stroke of the non-dominant hemisphere, The synergistic effect between the two hemispheres is the key mechanism of PSA recovery.