Biochemical markers as prognostic indicators in cholelithiasis among alcoholics

Gallstones disease provides significant input to surgical opd and cause morbidity worldwide. Cholelithias is develops because of an imbalance in the chemical composition of bile inside the gallbladder and it is due to multifactorial etiology which include chronic alcoholism. Symptomatic patient's will undergo cholecystectomy. The important complications of long term gallstones are acute pancreatitis, cholecystitis, obstructive jaundice which alter the liver function and decrease the life expectancy. The present study was conducted in vinayaka mission medical college and hospital, karaikalto assess the biochemical markers as prognostic indicators in patients with cholelithiasisamong alcoholics. A total of 22 patients (case) in which 11 alcoholics and 11 non alcoholics who were age and sex matched with multiple stones in gall bladder, symptomatic and undergoing cholecystectomy were recruited for this study. 25 normal individuals as controls were recruited for this study. Serum total and direct bilirubin were estimated by DMSO method. Serum SGPT, SGOT, GGT, Lipase, Amylase and Serum alkaline phosphatase level were estimated .In the present study liver function biochemical parameters were found to increase in alcoholic gallstone disease individuals when compared to healthy individuals and also compared to gallstone disease nonalcoholic subjects. ALP and Direct billirubin were significantly elevated in alchoholic gallstone disease subjects (p=0.01,p=0.04) when compared to healthy individuals. Thus elevated biochemical parameter levels in blood could predict the presence of liver damage and also indicates the severity of gallstone disease and its complications among alcoholics.