Protective effect of curcumin on lindane-induced nephrotoxicity in male wistar rats

Lindane; an organochlorine pesticide has been used in agriculture and domestic purposes for several years. The aim of present study was to analyze the oxidative effect of lindane which caused biochemical and ultrastructural changes in adult male wistar rats and to evaluate the possible protective effect of curcumin. Tissues damage was assessed by histopathological observation. Curcumin plays an important role as an antioxidant and is consequently expected to protect tissues from damage caused by reactive oxygen metabolites. Rats were divided into seven goups. Group-A, was given normal diet and water ad libitum. Lindane (30 mg/kg body weight) was administered orally for 14 and 28 days in group- B and group-C respectively. Curcumin (100 mg/kg body wt) was given to Group-D and Group-E. Lindane (30 mg/kg body wt) along with curcumin (100 mg/kg body wt) was administered orally for 28 days in group-F. Group-G, was allowed to metabolized after 14 days of exposure to lindane. Lindane administration lead to a significantly (p<0.001) increase in renal lipid peroxidation associated with reduction in levels of GSH, activity of SOD, CAT and GST. Pre-feeding and post-feeding of curcumin resulted in decreased renal levels of lipid peroxides and increased GSH, SOD, CAT and GST activities. Results revealed that curcumin in combination with lindane partially or totally alleviated its toxic effects on the studied parameters. In conclusion, Curcumin have beneficial effects and could be able to antagonize lindane toxicity.