Triazoles can exists in two viz. 1,2,3- and 1,2,4- isomeric forms. The compounds with 1,2,4-triazole ring core have attracted the researchers all over the world due to their broad spectrum of synthetic and biological activities. There has been a significant interest in recent years in developing simple, clean, non-toxic, cost-effective and eco-friendly procedures for the synthesis with or without metal catalysts, and the exploration of these molecules to wide range of biological potencies. In this review, we have summarized the recent developments in the synthesis and their medicinal potencies of 1,2,4-triazole derivatives and the reports have been critically discussed.
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