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Alzheimers disease and periodontitis – a correlation

Author: 
Dr. Amit K Walvekar, Dr. Meharunneesa Nallakkendavida, Dr. Amitha Sathish Dr. Ammu Jose Paul and Dr. Kith P Jose
Subject Area: 
Health Sciences
Abstract: 

Background: In spite of the relatively minimal knowledge on the etiology and pathogenesis of Alzheimer’s disease inflammatory activity in the brain has been proposed to be the most plausible cause. Researches have indicated that, peripheral infection /inflammation can have an impact on infection in central nervous system. Chronic periodontitis is a common peripheral infection with predominant bacterial etiology and a marked increase in the serum C Reactive Protein count. Periodontitis, lately has been known to be involved in various systemic diseases including Alzheimer’s disease. Methods: A literature review was performed by referring to the scientific papers on the internet from the PubMed and Google Scholar and databases from 1985 to 2019 The present article reviews the pathogenesis of periodontitis associated with Alzheimer’s disease along with few probable mechanism by which periodontitis can contribute to Alzheimer’s disease. Result: Periodontal disease can influence Alzheimer's disease through different mechanism. Conclusion Because Periodontitis is a treatable disease it could be a modifiable risk factor for Alzheimer's disease.

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