Antihyperlipidaemic activity of allium sativumleaves methanolic extracts of triton wr -1339 induced hyperlipidaemic rats

Hyperlipidaemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidaemia has no side effects and is relatively cheap and locally available.Literature claims that Saponins are able to reduce hyperlipidemia. Based on high content of saponin in herbal plants, Garlic (Allium sativum L.) was selected and focus on the anti-hyperlipidemic activity of ethanolic seed extract of Allium sativum Lagainst triton-WR1339 induced hyperlipidemia in rats. Hyperlipidemia was induced in Wistar rats by Intraperitoneal (I.P) injections of Triton WR-1339 at a dose of 400 mg/kg body weight. Allium sativum L was administered orally at a dose of 200 mg/kg to triton WR-1339 induced hyperlipidaemic rats. After administration of Allium sativum L shows a significant decrease in the levels of cholesterol, phospholipids, triglycerides, LDL, VLDL and significant increase in the level of HDL in serum and liver tissues against triton induced hyperlipidaemic in rats. Therefore it effectively suppressed the triton induced hyperlipidemia in rats, suggesting the potential protective role in Coronary heart disease.