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Antioxidant and Hepatoprotective potential of the aqueous decoction from Siddha formulation drug Karisalai Karpam

Author: 
Bharathkumar, G., Kanagavalli, K., Bama, P., Sankaranarayanan, S. and Pitchiah Kumar, M.
Subject Area: 
Health Sciences
Abstract: 

The present study was conducted to evaluate the antioxidant and hepatoprotective potential of Karisalai Karpam. Antioxidant activity of the aqueous decoctionof Karisalai Karpam was studied using in vitro and in vivo models, phytochemical screening result revealed the presence of alkaloid, flavonoid, tannin, flavonoid, anthocyanin, terpenoid and absence of glycosides. The Karisalai Karpam exhibited strong free radical scavenging activity as evidenced by the highest activity values in ABTS (2,2'-azino-bis-3-ethyl benzthiazoline-6-sulphonic acid) (74.23%), lipid peroxidation (81%), superoxide anion (79.5%), Metal chelating activity (84.05%), and nitric oxide scavenging activity (81.45) methods. Hepatoprotective activity of Karisalai Karpam was determined by the alcohol induced oxidative tissue injury in rat liver, the aqueous decoctionshowed significant hepatoprotective activity that was evident by enzymatic examination and histopathological study. This study provides a scientific basis for the ethnomedical claims that Karisalai Karpam is effective against ageing related diseases and liver injury.

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