
Antiphospholipid syndrome (APS) is presented with thrombocytopenia, recurrent foetal loss, arterial & venous thrombosis. Primary APS is common compared to secondary one. Here we presented a 25 years old male with progressive exertional chest heaviness over last one year and diagnosed as chronic stable angina. Coronary angiography (CAG) revealed acute thrombotic occlusion of proximal left anterior descending (LAD) artery and underwent primary percutaneous transluminal angioplasty (PTCA) and stenting. Subsequently he received dual antiplatelet and anticoagulant.