Clinicopathological characteristics and outcomes of gallbladder cancer: a single-institution experience

Background/Aim: This study aims to determine the clinicopathological characteristics and outcomes of gallbladder cancer during the last nine years. Settings and Design: Retrospective chart review of the demographic and clinical profiles of gallbladder patients followed up at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, for the period of 2008–2017. Methods and Material:We collected data demographic and clinical data (histopathological features, radiological findings, date of diagnosis, type of surgical treatment offered, type of chemotherapy, radiation therapy, intervention used, disease progression, date of the last follow up, date of recurrence, and date of death). Statistical Analysis: The Cox proportional hazards model was used for the univariate analysis and multivariate analysis model building. Results and Conclusions: A total of 21 patients were included in this study, with females representing 66.7% of the sample. The mean age of the patients was 57 years. Among the cases, 13 (61.9%) were identified as adenocarcinoma, and five (23.8%) were classified as dysplasia; the least frequent histologic diagnosis wascarcinosarcoma (n = 1, 4.8%).Tumor resection was performed in 14patients. Of these, 13 had a laparoscopic cholecystectomy, whereas only one case hadhepaticoenterostomy. Univariate analysis did not demonstrate significant differences in overall survival by age, gender, histologic subtype, tumor grade, surgical margin status, lymph node invasion, or tumor marker status. We did not identify predictors of outcome in patients who were followedup and treated for gallbladder cancer at our institution. Future larger studies are warranted to study the patterns of outcome in our context.