Background: The objective of this study was to compare the effectiveness of Periosteal pedicle membrane with DFDBA versus open flap debridement with PRF in Grade II/III furcations defects Methods: The study population included 10 subjects, who visited the out-patient department of periodontics, Govt Dental College and Hospital Srinagar with complaint of bleeding and sensitivity, diagnosed as chronic periodontitis. After conducting routine examinations, Relative attachment and probing depth and Horizontal defect fill was measured were measured. The measurement of Relative attachment was made with ocllusal stent as guiding value. Test side operated (Periosteal pedicle membrane with DFDBA)), on contralateral control side Open flap debridement with PRF was done. Results: Results showed that Patients treated with periosteal pedicle membrane in combination with DFDBA graft in Grade II/ III showed favourable results in test group than control (open flap debridement with PRF) as per Relative attachment level and furctaion defect fill is concerned. Conclusion: within the limitations of this study, it can be concluded that space provision by an alloplastic graft material increases the regenerative potential of periosteal pedicle graft.