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Covid-19 and guillain-barré syndrome: a parallel with other viral infections

Author: 
Amanda Maria Lemos da Silva, Ana Carolina Paiva Farias, Davi Emanuel Fonseca de Assis, Márcia Noelle Cavalcante Medeiros, Raphael Nascimento Cirino, Thayane Araújo Lima, and Luiz Severo Bem Junior
Subject Area: 
Health Sciences
Abstract: 

Background: In view of the pandemic insurgency caused by the new coronavirus, whose clinical picture ranges from asymptomatic to respiratory failure, some clinical associations with syndromes and diseases have been raised, among them Guillain-Barré Syndrome (GBS). In order to bring more clarification, a study was carried out in order to define and analyze neurological disorders by Covid-19, in addition to making comparisons with other viral diseases. Methods: Integrative review based on the Pubmed database. A reading of titles and abstracts was done by 3 reviewers, in a blind and independent way, followed by a complete reading, concluded in the choice of 10 articles. These were reassessed, now by 6 evaluators, for collection, data analysis and weighting according to quality scales. Results: the studies seem to reveal a possible association between Covid-19 and SBG, either by a predominantly post-infectious profile, with an average latency time of 5-10 days; higher prevalence in men and with a mean age of 62.4 years. Discussion / Conclusion: GBS is often preceded by infectious exposure. It is possible for SARS-CoV-2 to gain entry into the central nervous system through systemic vascular dissemination or the cryptous plaque of the ethmoid bone, causing from headache to flaccid flaccid paralysis (characteristic of GBS). In Zika virus involvement, this mechanism is still not well understood. Therefore, there seems to be an association between Covid-19 and GBS with a post-infectious profile, but these are larger studies for further clarification.

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