Evaluation of acute toxicity of mahachaitasa ghrita

Mahachaitasa Ghrita is an Ayurvedic polyherbal ghee preparation mainly indicated for Sarvachetovikara (all disorders of mind), especially Unmada (Insanity) and Apasmara (Epilepsy) and it is an effective drug for this condition. Continuous administration of any medications may lead to some adverse effects on the body. So it is necessary to assess the toxicity of Ayurvedic formulations. Here in this study, 6 rats were administered Mahachaitasa Ghrita for 14 consecutive days and assessed in-life observation of rats, change in body weight, food intake, and water intake. Haematological and biochemical parameters were assessed before and after the study. The histopathology of the Liver and Kidneys were also analyzed. The in-life observation and other general observations showed no adverse effects after a 14-day pretreatment with Mahachaitasa Ghrita. Haematological and biochemical parameters had shown significant improvement in all parameters in the rats. The histopathology of the liver and kidney showed only mild changes. So we can suggest that Mahachaitasa Ghrita could be a safe drug for a 14-day administration at a dose of 4.93 g/kg in Wistar Albino rats.