Malaria is a destructive disease distressing human being caused mostly by mosquitoes. In general this disease can be avoided by preventing mosquito bites by mosquito net and chemical repellents. Chemical repellents which are applied in cloth are allergic to human and create irritations on skin and breathing troubles. In order to avoid problems of chemical repellents a research attempt has been made to treat cotton bed spreads with the extract of naturally available Senna Auriculata flowers which has mosquito repellency which helps in protecting human from mosquito bites and it is environmental friendly too. The effects of the extract of naturally available Senna Auriculata flowers on Cotton/Polyester blended bedspread for the repellency towards the mosquitoes were evaluated by Cage Test. The result show that the natural extract from Senna Auriculata flowers gives excellent mosquito repellency on cotton/polyester blended bedspreads.