Inclusions in erythrocytes: interpretations

Erythrocyte inclusions are seen in many hematological disorders, both benign and malignant. Some of the common hematological disorders are anemias, which often have vague and frequently overlapping symptoms. Erythrocyte inclusions may be pathological evidence of specific diseases or disorders when interpreted within the context of presenting clinical symptoms and signs. Characterizing and identifying RBC inclusions can provide or support the diagnosis of various clinical conditions. The main aim of this review is to study the morphological characteristics, staining patterns, and clinical correlation of the most common erythrocyte inclusions.