Pathogenesis of h. pylori infection

Background: The aim of this study is to find out association of H.Pylori and acid peptic disease in patients with symptoms of Dyspepsia. Materials and Methods: 100 patients presenting with the symptoms of dyspepsia who underwent upper GI Endoscopy in department of surgery and those refered pathology department for histopathology. Results: Majority of patients were male and age group between 20 to 39 years i.e 47%. On endoscopy majority of the findings were gastritis 35% patients, followed by duodenitis 22% pts, esophagitis 19% patients, gastric ulcer in 5% pts, duodenal ulcer in 4% pts and 2% pts had gastric cancer. 13% patients has normal on endoscopic findings. The highest positivity of RUT was seen in pts of Gastritis 91.42% and duodenitis 81.81%, followed by esophagitis 68.42%. The positivity of RUT in gastric ulcer and duodenal ulcer was 80 % and 75 % rescpectively. Pts with normal mucosa having 69.23% RUT positive. culture was positive in 17 pts. H. Pylori was isolated from 7% pts of gastritis, 4% pts in duodenitis, 1% from gastric ulcer, 2% from duodenal ulcer and 3% patients with normal scopy findings. Conclusion: H.Pylori is now widely recognized as the most common cause of primary or unexplained gastritis in patients present with the symptoms of Dyspepsia and RUT is accurate for the diagnosis of H. pylori infection.