Pharmacological evaluation of neuro protective effect of ferulic acid in animal model of neuropathy

Aim: Pharmacological evaluation of neuro protective effect of Ferulic acid in animal model of neuropathy. Materials and Methods: Diabetes was induced in rats by intraperitoneal injection of single dose of STZ (60 mg/kg). Neuropathic pain was assessed in diabetic rats by pin prick method, cold allodynia and hot plate method. Pain was developed at 4th week. At the end of experiment animals were scarified and biochemical changes (Lipid peroxidation, SOD, reduced glutathione and CAT content) in sciatic nerve were evaluated. Animals were treated with Ferulic acid doses (50, 100 and 150 mg/kg i.p) for 4th week. Results: Treatment with Ferulic acid at doses of 50,100 and 150 mg/kg significantly restored the reduced body weight, food, water and elevated blood sugar level. Further the drug Ferulic acid showed dose dependent reduction in pain threshold tested by mechanical, cold and thermal hyperalgesia. The level of lipid peroxidation, reduced glutathione, SOD and CAT content was significantly prevented. The blood serum level on sodium, potassium, urea, uric acid and creatinine content was significant prevented. Conclusion: The result of present study suggests the antidiabetic, antioxidant and neuroprotective property of Ferulic acid in laboratory animals.