Podoplanin and ki-67 as future prognostic markers in gliomas

Background and Objective: Gliomas are the most common central nervous system tumors. Prognostic and predictive markers play an important role in clinical practice for the assessment of prognosis and the selection of appropriate therapy. The aim of this study to assess the immunohistochemistry status of podoplanin and Ki67 in low grade and high grade gliomas and correlating them with histopathological grading, treatment and overall survival of the patients. Material and Methods: This analytical study of the 2 year duration on 150 glial tumor tissue was done which were processed accordingly and grading was done after H &E staining. The scoring of podo was divided into podo score 1: focal staining (0-2) and podo score 2: extensive staining (3-4).The scoring of Ki67 was calculated as Score 1 :< 4%, Score 2 :4-10 & Score 3 :> 10%. Result: Majority of cases having podo score 1 were of low grade glioma while majority of cases with podo score 2 were high grade glioma. Podoplanin and Ki-67 scoring increased with increasing grade of glial tumors. Mean survival duration of cases who received radiotherapy was significantly higher as compared to those who did not receive radiotherapy. Conclusion: Till present date the long term survival of patients suffering from malignant gliomas remains low, which points the need for new independent prognostic factors. In search of this emerging need we found of podoplanin and Ki-67 really promising.