Background: Tooth extraction considered one of the most common dental procedures that require the applying of local anesthesia. The aim of this study was to compare the pain during injection and during extraction between two techniques of local anesthesia, intraligamentary injection technique and mental incisive nerve block technique. Materials and Methods: Thirtymandibular premolars \ incisors, which was indicated for extraction, were selected for this study & two different techniques of local anesthesia, intraligamentary and mental incisive nerve block, were compared during injection and during extraction with the use of universal pain assessment tool as parameters. Results: The painat the time of injection was higher for patient having MINB than ILI. However, the pain at the time of extraction was lower for patient having MINB than ILI. Conclusion: ILI appears less painful during injection and provides sufficient pain relief during extraction. On the other hand, MINB can be used as it provides higher extraction¬ pain relief.