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The role of mdr1 (c3435t) gene polymorphism in patients with chronic obstructive pulmonary Disease associated with type 2 diabetes mellitus

Author: 
Natalia V. Chernetska, Hanna Ya. Stupnytska and Oleksandr I. Fediv
Subject Area: 
Health Sciences
Abstract: 

Chronic obstructive pulmonary disease is a multifactorial disease characterized by gene-gene interaction as well as environmental effects. The incidence of type 2 diabetes mellitus with chronic obstructive pulmonary disease is proved to be higher than in case of its absence.All the patients were divided into two groups. The first group included 53 patients with chronic obstructive pulmonary disease. The second group included 49 patients with chronic obstructive pulmonary disease with comorbid type 2 diabetes mellitus. CAT test, 6-minute walk test, BODE integral index, spirometry, bioimpedansometry were used for examination. Lipid spectrum, carbohydrate metabolism, endothelial functional status, leptin, adiponectin and serum levels were also determined by means of enzyme immunoassay. The results of our study showed that there is no significant difference between the genotypes of the control group of healthy individuals and patients with chronic obstructive pulmonary disease and comorbid type 2 diabetes mellitus. Though, certain association of this gene polymorphism with clinical findings by CAT-test, certain parameters of carbohydrate (fasting glucose) and lipid metabolism (total cholesterol and low density cholesterol lipoproteins), endothelial functional state (nitrate / nitrite level) with minor allele T available is found. Further investigation is required and possible use of the findings obtained to be implemented in personalized treatment in case of comorbidity of chronic obstructive pulmonary disease and type 2 diabetes mellitus, taking into account MDR1 (S3435T) gene polymorphism.

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