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Serum transaminases and calcium levels in patients with dengue fever: a hospital based study

Author: 
Ashok Kumar Shah, Arpita Suri, Birendra Kumar Yadav, Nisha Chauhan, Sanjiv Kumar Bansal, Busi Karunanand
Subject Area: 
Health Sciences
Abstract: 

Background & Objectives: Dengue fever is associated with significant morbidity and mortality there by initiation of timely management of the patient to prevent complications is the need of the time. Our study focuses on biochemical alterations associated with dengue fever which would help in early identification and management of patients. Materials & Methods: In this case-control study, clinically diagnosed patients of dengue (n=50) and age-matched healthy controls (n=50) were enrolled. Serum bilirubin, transaminases and calcium levels were estimated in both the groups and further compared using Independent student’s t-test. Results: The mean level of serum bilirubin in patients with dengue fever were significantly higher (p<0.01) than controls. The mean serum levels of both the liver enzymes, Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) were significantly increased (p<0.000) whereas the mean serum calcium level of dengue patients was significantly decreased (p<0.000) than the healthy controls. Interpretation & Conclusion: Dengue fever is characterized by various biochemical attentions such as increased transaminases, raised bilirubin and low calcium. These investigations will help in early identification, diagnosis and management of dengue patients.

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